Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 411
interventional 290
Observational 110
Registry 11

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 91
Drug|placebo 77
Device 37
Biological 20
Other 15
Procedure 13
Behavioral 7
Dietary Supplement 6
Biological|placebo 3
Biological|Drug 2
Device|Drug|Other|Procedure 2
Diagnostic Test 2
Dietary Supplement|placebo 2
Behavioral|Device 1
Biological|Device 1
Biological|Other 1
Biological|Other|placebo 1
Biological|Procedure 1
Combination Product|placebo 1
Device|Other 1
Device|Procedure 1
Drug|Other 1
Drug|Procedure 1
Genetic 1
Other|placebo 1
placebo|Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 119
France 19
Italy 14
NA 11
United Kingdom 9
Australia 8
Canada 8
Japan 8
Spain 8
Germany 7
Israel 6
Korea, Republic of 6
Iran, Islamic Republic of 5
United States|Canada 5
Taiwan 4
Brazil 3
China 3
Belgium|France|Germany|Spain|United Kingdom 2
Denmark 2
Lebanon 2
Mexico 2
United States|Belgium|Canada|France|Germany|Ireland|Italy|Netherlands|Portugal|Spain|United Kingdom 2
United States|Belgium|Canada|France|Germany|Italy|Netherlands|Poland|Spain|Sweden|Switzerland|United Kingdom 2
Austria|Belgium|France|Germany|Italy|Netherlands|Switzerland|United Kingdom 1
Belgium 1
Belgium|France|Germany|Ireland|Italy|Netherlands|United Kingdom 1
Belgium|France|Germany|Israel|Italy|United Kingdom 1
Belgium|France|Germany|Italy|Netherlands|Switzerland|United Kingdom 1
Canada|United States|Australia|Ireland|Netherlands|Spain 1
France|Italy|Spain|United Kingdom 1
France|United Kingdom 1
Germany|Ireland|Netherlands|United Kingdom 1
Guadeloupe|Martinique 1
Malaysia 1
Netherlands 1
Norway|Portugal 1
Poland 1
Portugal 1
Russian Federation|United Kingdom 1
Singapore 1
Switzerland 1
United States|Australia|Austria|Belgium|Canada|Finland|France|Germany|Ireland|Italy|Netherlands|Spain|Sweden|United Kingdom 1
United States|Australia|Belgium|Canada|France|Germany|Ireland|Netherlands|Spain|Sweden|United Kingdom 1
United States|Australia|Belgium|Canada|France|Germany|Italy|Japan|Korea, Republic of|Netherlands|United Kingdom 1
United States|Australia|Belgium|Canada|France|Germany|Italy|Japan|United Kingdom 1
United States|Belgium|Canada|France|Germany|Hungary|Israel|Italy|Netherlands|Spain 1
United States|Belgium|Canada|France|Germany|Italy|Netherlands|Switzerland|United Kingdom 1
United States|Canada|France|Germany|Ireland|Netherlands|Spain|United Kingdom 1
United States|Canada|Netherlands 1
United States|Canada|Netherlands|Switzerland|United Kingdom 1
United States|Czech Republic|Hungary|Poland 1
United States|Finland|Sweden 1
United States|France|Italy|United Kingdom 1
United States|Germany|Italy|Sweden 1
United States|Italy 1
United States|Netherlands 1
United States|Puerto Rico 1
United States|United Arab Emirates 1

Sites per Study

Site_count Study_Count
1 165
2 29
3 11
4 12
5 4
6 5
7 2
8 1
9 5
10 8
11 5
12 4
13 2
15 4
17 5
18 1
19 3
20 2
21 1
22 1
23 1
24 1
25 3
26 1
29 2
30 1
31 1
35 1
42 1
44 1
58 1
64 1
67 1
75 1
81 1
82 1
104 1

Phase

Phase Study_Count
Phase 2 95
N/A 75
Phase 1 39
Phase 1/Phase 2 28
Phase 3 26
Phase 2/Phase 3 18
Early Phase 1 6
Phase 4 3

Number of Arms

Number_of_Arms Count_of_Studies
1 98
2 116
3 35
4 10
5 3
6 4
10 1
NA 23

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 2.00 1.00000 1.00000 9.00000 3.000 14.0000 13.0000 23.0
1st Qu. 9.50 15.50000 12.00000 17.25000 23.000 38.5000 109.2500 31.5
Median 20.50 39.00000 27.00000 28.00000 43.000 71.5000 231.0000 40.0
Mean 20.50 68.01333 36.41026 29.96429 1167.237 163.6111 278.8462 159.0
3rd Qu. 23.25 62.50000 55.00000 36.25000 90.000 237.5000 430.0000 227.0
Max. 50.00 800.00000 200.00000 72.00000 100000.000 750.0000 943.0000 414.0

Trial Group Type

group_type Group_Count
Experimental 305
Placebo Comparator 98
Active Comparator 77
Other 31
NA 23
No Intervention 8
Sham Comparator 5

Intervention Model

intervention_model Study_Count
Parallel Assignment 150
Single Group Assignment 112
Crossover Assignment 15
Sequential Assignment 8
NA 4
Factorial Assignment 1

Primary Purpose

primary_purpose Study_Count
Treatment 219
Supportive Care 20
Other 15
Basic Science 12
Diagnostic 9
NA 6
Health Services Research 4
Prevention 3
Device Feasibility 2

Observational Studies

Studies by Country

Country Study_Count
United States 65
France 8
Italy 4
United States|Canada 4
Canada 3
China 3
NA 3
Belgium 2
Denmark 2
Norway 2
Spain 2
United Kingdom 2
Denmark|Turkey 1
Germany 1
Israel 1
Portugal 1
Switzerland 1
Taiwan 1
United States|Belgium|Canada|France|Germany|Ireland|Netherlands|Switzerland|United Kingdom 1
United States|Germany|South Africa 1
United States|Netherlands 1
United States|United Kingdom 1

Sites per Study

Site_count Study_Count
1 84
2 5
3 3
5 2
6 3
8 3
9 2
12 1
14 1
15 1
18 1
19 1
21 1
30 1
39 1

Enrollment Metrics

Measure Observational
Min 0.0000
1st Qu 43.2500
Median 104.5000
Mean 763.5364
3rd Qu 348.7500
Max 15000.0000

Observation Model

observational_model Study_Count
Cohort 44
Case-Control 17
NA 15
Case-Only 14
Case Control 7
Other 7
Family-Based 3
Defined Population, Natural History 2
Case-Crossover 1

Time Perspective

time_perspective Study_Count
Prospective 70
Cross-Sectional 14
NA 12
Retrospective 7
Other 5
Cross-Sectional, Retrospective 1
Longitudinal, Prospective 1

Registries

Studies by Country

Country Study_Count
United States 5
China 1
France 1
Germany 1
Israel 1
NA 1
Spain 1

Sites per Study

Site_count Study_Count
1 9
8 1
13 1

Enrollment Metrics

Measure Registries
Min 16.000
1st Qu 35.000
Median 350.000
Mean 2406.091
3rd Qu 1524.500
Max 17000.000

Registry Model

observational_model Study_Count
Case-Control 4
Case-Only 3
Cohort 3
Other 1

Time Perspective

time_perspective Study_Count
Prospective 7
Cross-Sectional 2
Other 2

Follow-up

target_duration Study_Count
1 Day 2
1 Year 2
10 Years 2
3 Years 2
5 Years 1
6 Months 1
9 Months 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04454840 Treatment of Intravenous Infusion Plasma in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT04454840 Completed Peking University Third Hospital 2019-05-01
NCT04288856 Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB078 Administered to Previously Treated Adults C9ORF72-Associated Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT04288856 Enrolling by invitation Biogen 2023-07-19
NCT03427086 Safety and Tolerability of High Dose Biotin in Patients With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03427086 Recruiting American University of Beirut Medical Center 2021-01-10
NCT03377309 Safety and Tolerability of Perampanel in Amyotrophic Lateral Sclerosis Patients https://ClinicalTrials.gov/show/NCT03377309 Recruiting American University of Beirut Medical Center 2022-06-01
NCT03367650 Epidemiology and Genetics of the Amyotrophic Lateral Sclerosis in the French West Indies https://ClinicalTrials.gov/show/NCT03367650 Recruiting Centre Hospitalier Universitaire de Pointe-a-Pitre 2020-05-13
NCT03359538 Rapamycin Treatment for ALS https://ClinicalTrials.gov/show/NCT03359538 Active, not recruiting Azienda Ospedaliero-Universitaria di Modena 2020-12-15
NCT03326622 Exercise and Disease Progression in Amyotrophic Lateral Sclerosis Patients https://ClinicalTrials.gov/show/NCT03326622 Completed University of Lisbon 2015-03-30
NCT03324399 A Study of Protein Metabolism, Microbiome and Investigational Probiotic Use in Patients With ALS https://ClinicalTrials.gov/show/NCT03324399 Completed Avera McKennan Hospital & University Health Center 2019-06-26
NCT03321487 Blood-Brain Barrier Opening Using MR-Guided Focused Ultrasound in Patients With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03321487 Active, not recruiting InSightec 2020-12-31
NCT03293069 Conservative Iron Chelation as a Disease-modifying Strategy in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03293069 Recruiting University Hospital, Lille 2022-03-31
NCT03296501 Intraspinal Transplantation of Autologous ADRC in ALS Patients https://ClinicalTrials.gov/show/NCT03296501 Active, not recruiting Mossakowski Medical Research Centre Polish Academy of Sciences 2020-10-31
NCT03293394 Rehabilitative Trial With tDCS in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03293394 Completed Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia 2018-06-20
NCT03280056 Safety and Efficacy of Repeated Administrations of NurOwn® in ALS Patients https://ClinicalTrials.gov/show/NCT03280056 Active, not recruiting Brainstorm-Cell Therapeutics 2020-10-31
NCT03272802 Treatment Effect of Edaravone in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT03272802 Active, not recruiting Isfahan University of Medical Sciences 2019-03-16
NCT03272503 A Clinical Trial of Pimozide in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT03272503 Recruiting University of Calgary 2020-12-31
NCT03268603 Intrathecal Autologous Adipose-derived Mesenchymal Stromal Cells for Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT03268603 Recruiting Mayo Clinic 2022-12-31
NCT03214146 Safety/Efficacy Study of 2nd Cycle Treatment After 6 Months of 1st Cycle HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in ALS https://ClinicalTrials.gov/show/NCT03214146 Active, not recruiting Hanyang University Seoul Hospital 2019-03-25
NCT03204500 Dual Treatment With Lithium and Valproate in ALS. https://ClinicalTrials.gov/show/NCT03204500 Active, not recruiting El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez 2019-04-30
NCT03202017 Lung Volume Recruitment Combined With Expiratory Muscle Strength Training in ALS https://ClinicalTrials.gov/show/NCT03202017 Recruiting University of Minnesota 2020-12-31
NCT03201991 ALS Study Determining Various Biomarkers and Strength Comparison After Exercise https://ClinicalTrials.gov/show/NCT03201991 Completed University of Kansas Medical Center 2018-04-18
NCT03186040 Open-label Clinical Trial of Lacosamide in ALS https://ClinicalTrials.gov/show/NCT03186040 Recruiting Chiba University 2020-04-30
NCT03168711 Safety of Urate Elevation in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT03168711 Completed Massachusetts General Hospital 2019-12-10
NCT03160898 A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT03160898 Completed Cytokinetics 2019-03-07
NCT03136809 ALS Treatment Extension Study https://ClinicalTrials.gov/show/NCT03136809 Active, not recruiting Collaborative Medicinal Development Pty Limited 2020-12-31
NCT03127514 AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT03127514 Completed Amylyx Pharmaceuticals Inc. 2019-09-25
NCT03114215 Effect of MD1003 in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03114215 Completed MedDay Pharmaceuticals SA 2017-06-12
NCT03113630 Virtual Task in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03113630 Completed University of Sao Paulo 2016-08-03
NCT03095989 An Online Mindfulness Intervention for People With ALS and Their Caregivers https://ClinicalTrials.gov/show/NCT03095989 Completed Harvard University 2019-02-28
NCT03085706 Transplantation of Autologous Peripheral Blood Mononuclear Cells for Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03085706 Completed The First Affiliated Hospital of Dalian Medical University 2012-12-31
NCT03020797 A Clinical Trial to Evaluate the Safety and Efficacy of Fycompa in Subjects With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT03020797 Recruiting Stony Brook University 2019-12-31
NCT03019419 Perampanel for Sporadic Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT03019419 Active, not recruiting Tokyo Medical University 2022-12-31
NCT02987413 Escalated Application of Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis Patients https://ClinicalTrials.gov/show/NCT02987413 Completed Hospital e Maternidade Dr. Christóvão da Gama 2016-03-31
NCT02943850 CNS10-NPC-GDNF for the Treatment of ALS https://ClinicalTrials.gov/show/NCT02943850 Active, not recruiting Cedars-Sinai Medical Center 2019-10-31
NCT02936635 A Study for Patients Who Completed VITALITY-ALS (CY 4031) https://ClinicalTrials.gov/show/NCT02936635 Completed Cytokinetics 2018-10-26
NCT02891629 Safety and Feasibility of the EyeControl Device https://ClinicalTrials.gov/show/NCT02891629 Completed Eyefree Assisting Communication Ltd 2017-01-28
NCT02880033 Oxidative Stress and Apoptosis of Energy Metabolism by Deferiprone From the Circulating Lymphocytes https://ClinicalTrials.gov/show/NCT02880033 Completed University Hospital, Lille 2019-10-31
NCT02872142 Efficacy and Safety of Plasma Exchange With Albutein® 5% in Patients With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02872142 Completed Grifols Therapeutics LLC 2019-08-31
NCT02870634 Phase 1 Dose Escalation and PK Study of Cu(II)ATSM in ALS/MND https://ClinicalTrials.gov/show/NCT02870634 Completed Collaborative Medicinal Development Pty Limited 2019-10-30
NCT02868580 Safety and Tolerability of Antiretroviral (Triumeq) in Patients With Amyotrophic Lateral Sclerosis (ALS). https://ClinicalTrials.gov/show/NCT02868580 Completed Neuroscience Trials Australia 2017-12-31
NCT02868567 Use of Dalfampridine in Primary Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02868567 Recruiting Weill Medical College of Cornell University 2021-01-31
NCT02851914 SSRIs vs. TCAs for Depression in ALS Patients https://ClinicalTrials.gov/show/NCT02851914 Completed St. Louis University 2019-05-30
NCT02794857 Safety and Efficacy Study of NP001 in Patients With Amyotrophic Lateral Sclerosis (ALS) and Systemic Inflammation https://ClinicalTrials.gov/show/NCT02794857 Completed Neuraltus Pharmaceuticals, Inc. 2017-12-12
NCT02781454 Mexiletine in Sporadic Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02781454 Completed University of Washington 2018-09-30
NCT02759003 Nightime NIV Initiation in Amyotrophic Lateral Sclerosis in an Outpatient Setting https://ClinicalTrials.gov/show/NCT02759003 Completed Fondazione Salvatore Maugeri 2013-03-31
NCT02750982 Laughter Therapy Effects on Mood, Stress and Self-efficacy in People With Neurological Diseases. https://ClinicalTrials.gov/show/NCT02750982 Completed Brown, Theodore R., M.D., MPH 2018-08-31
NCT02714036 A Biomarker Study to Evaluate MN-166 (Ibudilast) in Subjects With Amyotrophic Literal Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT02714036 Active, not recruiting MediciNova 2019-12-31
NCT02710162 Accurate Screening Tools for Dysphagia in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT02710162 Completed University of Florida 2017-12-19
NCT02710110 Respiratory Strength Training in Persons With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT02710110 Completed University of Florida 2017-11-30
NCT02682030 The Use of Airway Clearance Devices in ALS https://ClinicalTrials.gov/show/NCT02682030 Completed Cedars-Sinai Medical Center 2018-12-31
NCT02670226 Muscular Biomarkers in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02670226 Active, not recruiting University Hospital, Tours 2020-09-30
NCT02655614 A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02655614 Active, not recruiting Genentech, Inc. 2020-08-01
NCT02645461 Acetylcholine Receptors From Human Muscles as Pharmacological Target for ALS https://ClinicalTrials.gov/show/NCT02645461 Completed University of Roma La Sapienza 2015-06-30
NCT02623699 An Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of BIIB067 in Adults With Inherited Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT02623699 Recruiting Biogen 2021-07-06
NCT02588677 Masitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT02588677 Completed AB Science 2016-12-05
NCT02795052 Neurologic Stem Cell Treatment Study https://ClinicalTrials.gov/show/NCT02795052 Recruiting MD Stem Cells 2022-06-30
NCT02437110 HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT02437110 Recruiting National Institutes of Health Clinical Center (CC) 2022-02-01
NCT02548663 Sport Therapy and Osteopathy Manipulative Treatment in ALS https://ClinicalTrials.gov/show/NCT02548663 Completed University of Milano Bicocca 2014-12-31
NCT02537132 “New Perspectives of Adaptation to NIV in ALS” https://ClinicalTrials.gov/show/NCT02537132 Completed Fondazione Don Carlo Gnocchi Onlus 2016-04-30
NCT02496767 Ventilatory Investigation of Tirasemtiv and Assessment of Longitudinal Indices After Treatment for a Year https://ClinicalTrials.gov/show/NCT02496767 Completed Cytokinetics 2017-03-09
NCT02492516 Intravenous Injection of Adipose Derived Mesenchymal Stem Cell for ALS https://ClinicalTrials.gov/show/NCT02492516 Completed Royan Institute 2017-03-31
NCT02487407 Effects of ODM-109 on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02487407 Completed Orion Corporation, Orion Pharma 2017-05-31
NCT02479802 Efficacy and Safety of Plasma Exchange With Albumin in Patients With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02479802 Completed Grifols Biologicals, LLC 2016-06-30
NCT02469896 A Trial of Tocilizumab in ALS Subjects https://ClinicalTrials.gov/show/NCT02469896 Completed Barrow Neurological Institute 2018-07-11
NCT02469675 Brain and Nerve Stimulation for Hand Muscles in Spinal Cord Injury and ALS https://ClinicalTrials.gov/show/NCT02469675 Completed Bronx VA Medical Center 2018-07-31
NCT02464852 Assessment of the Effects of Sheffield Support Snood in MND Patients https://ClinicalTrials.gov/show/NCT02464852 Completed Sheffield Teaching Hospitals NHS Foundation Trust 2015-12-31
NCT02464748 Telehealth in Motor Neurone Disease https://ClinicalTrials.gov/show/NCT02464748 Completed Sheffield Teaching Hospitals NHS Foundation Trust 2016-04-30
NCT02463825 A Registry-Based Clinical Trial of Pimozide in Patients With Neuromuscular Junction Transmission Dysfunction Due to ALS https://ClinicalTrials.gov/show/NCT02463825 Active, not recruiting University of Calgary 2016-08-31
NCT02460679 Safety and Biomarker Study of EPI-589 in Subjects With ALS https://ClinicalTrials.gov/show/NCT02460679 Completed Edison Pharmaceuticals Inc 2018-07-31
NCT02450552 Clinical Trial of Ezogabine (Retigabine) in ALS Subjects https://ClinicalTrials.gov/show/NCT02450552 Completed Massachusetts General Hospital 2018-01-31
NCT02447952 Exploratory Study of Biotelemetry in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02447952 Completed GlaxoSmithKline 2017-06-01
NCT02418546 Electronic-health Application To Measure Outcomes REmotely Clinical Trial https://ClinicalTrials.gov/show/NCT02418546 Completed Massachusetts General Hospital 2017-12-31
NCT02383654 Compassionate Treatment : An Exploratory Clinical Trial to Assess Treatment of Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02383654 Completed China Medical University Hospital 2016-01-31
NCT02313402 A New Eye-based Communication Device for ALS Patients https://ClinicalTrials.gov/show/NCT02313402 Completed Assistance Publique - Hôpitaux de Paris 2015-04-30
NCT02306590 Efficacy, Safety and Tolerability of High Lipid and Calorie Supplementation in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02306590 Completed University of Ulm 2018-01-31
NCT02306109 Effect of Motor Rehabilitation Treatment on Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT02306109 Completed Azienda Unita’ Sanitaria Locale Di Modena 2017-12-31
NCT02290886 A Multicenter Phase I/II Clinical Trial to Evaluate Safety of Mesenchymal Stem Cell in Patients With Amyotrophic Sclerosis Lateral https://ClinicalTrials.gov/show/NCT02290886 Active, not recruiting Andalusian Network for Design and Translation of Advanced Therapies 2020-12-31
NCT02288091 A Pilot Study of Inosine in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT02288091 Completed Massachusetts General Hospital 2016-03-31
NCT02238626 Ibudilast (MN-166) in Subjects With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT02238626 Completed MediciNova 2017-08-31
NCT02236897 PET Imaging in ALS Patients https://ClinicalTrials.gov/show/NCT02236897 Completed Johns Hopkins University 2017-03-31
NCT02236065 Combination Therapy of Cord Blood and G-CSF for Patients With Brain Injury or Neurodegenerative Disorders https://ClinicalTrials.gov/show/NCT02236065 Completed Bundang CHA Hospital 2016-07-31
NCT02166944 Tamoxifen Treatment in Patients With Motor Neuron Disease https://ClinicalTrials.gov/show/NCT02166944 Completed Taipei Medical University Shuang Ho Hospital 2019-09-17
NCT02164253 Focal Accumulation of Iron in Cerebral Regions in Early ALS (Amyotrophic Lateral Sclerosis) Patients https://ClinicalTrials.gov/show/NCT02164253 Completed University Hospital, Lille 2016-12-31
NCT02152449 Oral Nutritional Supplementation in Amyotrophic Lateral Sclerosis (ALS) Patients https://ClinicalTrials.gov/show/NCT02152449 Active, not recruiting University Hospital, Limoges 2019-07-31
NCT02118727 Therapy in Amyotrophic Lateral Sclerosis (TAME) https://ClinicalTrials.gov/show/NCT02118727 Recruiting University of Kansas Medical Center 2022-10-31
NCT02059759 Immuno-modulation in Amyotrophic Lateral Sclerosis- a Phase II Study of Safety and Activity of Low Dose Interleukin-2 https://ClinicalTrials.gov/show/NCT02059759 Completed Centre Hospitalier Universitaire de Nīmes 2015-12-31
NCT01285583 Safety Extension Study of TRO19622 in ALS https://ClinicalTrials.gov/show/NCT01285583 Completed Hoffmann-La Roche 2012-03-31
NCT01281631 A Study of NP001 in Subjects With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01281631 Completed Neuraltus Pharmaceuticals, Inc. 2012-09-30
NCT01281189 Phase 3 Study of Dexpramipexole in ALS https://ClinicalTrials.gov/show/NCT01281189 Completed Knopp Biosciences 2012-11-30
NCT02039401 Safety Study of VM202 to Treat Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02039401 Completed Helixmith Co., Ltd. 2015-09-30
NCT02017912 Phase 2, Randomized, Double Blind, Placebo Controlled Multicenter Study of Autologous MSC-NTF Cells in Patients With ALS https://ClinicalTrials.gov/show/NCT02017912 Completed Brainstorm-Cell Therapeutics 2016-03-31
NCT01995903 Developing a Discrimination Model to Diagnose ALS https://ClinicalTrials.gov/show/NCT01995903 Completed University of Michigan 2015-10-31
NCT01951924 LIME Study (LFB IVIg MMN Efficacy Study) https://ClinicalTrials.gov/show/NCT01951924 Completed Laboratoire français de Fractionnement et de Biotechnologies 2016-07-31
NCT01933321 Effect of Intrathecal Administration of Hematopoietic Stem Cells in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01933321 Completed Hospital Universitario Dr. Jose E. Gonzalez 2014-01-31
NCT01906658 A Study to Explore the Safety and Tolerability of Acthar in Patients With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT01906658 Completed Mallinckrodt 2014-11-30
NCT01900132 Electrical Impedance Myography: Exploratory Studies in Healthy People and People With Neuromuscular Disorders https://ClinicalTrials.gov/show/NCT01900132 Recruiting National Institutes of Health Clinical Center (CC) 2023-01-01
NCT01884571 Immunosuppression in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01884571 Completed Emory University 2016-01-31
NCT01879241 Study of Rasagiline in Patients With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT01879241 Completed University of Ulm 2016-04-30
NCT01854294 GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS) https://ClinicalTrials.gov/show/NCT01854294 Completed Genervon Biopharmaceuticals, LLC 2014-04-30
NCT01849770 Mexiletine in Sporadic Amyotrophic Lateral Sclerosis (SALS) https://ClinicalTrials.gov/show/NCT01849770 Completed University of Washington 2014-08-31
NCT01825551 The Effect of GCSF in the Treatment of ALS Patients https://ClinicalTrials.gov/show/NCT01825551 Completed Tehran University of Medical Sciences 2013-11-30
NCT01823380 Influence of the Vitamin D Blood Levels on the Amyotrophic Lateral Sclerosis Phenotype https://ClinicalTrials.gov/show/NCT01823380 Completed University Hospital, Montpellier 2014-02-28
NCT01811355 Mexiletine for the Treatment of Muscle Cramps in ALS https://ClinicalTrials.gov/show/NCT01811355 Completed University of California, Davis 2016-03-31
NCT01806857 Clinical Trial Nuedexta in Subjects With ALS https://ClinicalTrials.gov/show/NCT01806857 Completed Center for Neurologic Study, La Jolla, California, 2015-03-31
NCT01786603 Rasagiline in Subjects With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01786603 Completed University of Kansas Medical Center 2016-07-27
NCT01777646 Autologous Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF), in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01777646 Completed Brainstorm-Cell Therapeutics 2014-09-30
NCT01776970 Safety and Efficacy on Spasticity Symptoms of a Cannabis Sativa Extract in Motor Neuron Disease https://ClinicalTrials.gov/show/NCT01776970 Completed Ospedale San Raffaele 2015-12-31
NCT01759797 Intravenous Transplantation of Mesenchymal Stem Cell in Patients With ALS https://ClinicalTrials.gov/show/NCT01759797 Completed Royan Institute 2014-01-31
NCT01758510 Safety Study of HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT01758510 Completed Hanyang University Seoul Hospital 2017-04-10
NCT01753076 Study of Ozanezumab (GSK1223249) Versus Placebo in the Treatment of Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT01753076 Completed GlaxoSmithKline 2015-01-22
NCT01746381 Non-invasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) Using the iVAPS Mode https://ClinicalTrials.gov/show/NCT01746381 Completed McGill University Health Centre/Research Institute of the McGill University Health Centre 2019-12-31
NCT01709149 Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01709149 Completed Cytokinetics 2014-03-31
NCT01641965 Impact of Early Non Invasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) Patients https://ClinicalTrials.gov/show/NCT01641965 Completed Hospital Universitari de Bellvitge 2015-12-31
NCT01640067 Human Neural Stem Cell Transplantation in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01640067 Completed Azienda Ospedaliera Santa Maria, Terni, Italy 2015-12-31
NCT01639391 Creation of a Bank of Fibroblast From Patients With Amyotrophic Lateral Sclerosis: Pilot Study https://ClinicalTrials.gov/show/NCT01639391 Completed Institut Pasteur 2015-03-17
NCT01609283 A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT01609283 Completed Mayo Clinic 2019-01-31
NCT01605006 Humanitarian Device Exemption Post-Approval Study of NeuRx Diaphragm Pacing System for Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT01605006 Completed Synapse Biomedical 2017-02-28
NCT01551940 Toxin Treatment for Amyotrophic Lateral Sclerosis (ALS) Related Sialorrhea https://ClinicalTrials.gov/show/NCT01551940 Completed Hospices Civils de Lyon 2014-03-31
NCT01536249 Dexpramipexole and Cimetidine Drug Drug Interaction (DDI) https://ClinicalTrials.gov/show/NCT01536249 Completed Knopp Biosciences 2012-04-30
NCT01521728 Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01521728 Completed Johns Hopkins University 2016-02-29
NCT01511029 Study to Evaluate the QTC Interval in Healthy Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of the QRS Complex to the End of the T Wave Corrected for Heart Rate) https://ClinicalTrials.gov/show/NCT01511029 Completed Knopp Biosciences 2012-05-31
NCT01504009 Muscle Training of Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01504009 Completed University of Southern Denmark 2012-12-31
NCT01492686 Phase 3 Study of MCI-186 for Treatment of Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT01492686 Completed Mitsubishi Tanabe Pharma Corporation 2014-09-30
NCT01486849 Dose Titration Study to Test Safety and Effects of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01486849 Completed Cytokinetics 2012-03-31
NCT01449578 Dexpramipexole SAD/MAD Study https://ClinicalTrials.gov/show/NCT01449578 Completed Knopp Biosciences 2012-01-31
NCT01424163 Dexpramipexole Japanese PK Study https://ClinicalTrials.gov/show/NCT01424163 Completed Knopp Biosciences 2012-02-29
NCT01378676 A Study to Evaluate the Effects of Multiple Doses of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01378676 Completed Cytokinetics 2012-03-31
NCT01369901 Effect of Functional Exercise in Patients With Spinal Bulbar Muscular Atrophy https://ClinicalTrials.gov/show/NCT01369901 Completed National Institutes of Health Clinical Center (CC) NA
NCT01363401 Safety and Efficacy Study of Autologous Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT01363401 Completed Corestem, Inc. 2013-05-31
NCT04393467 Transcranial Static Magnetic Field Stimulation (tSMS) in Amyotrophic Lateral Sclerosis (ALS). https://ClinicalTrials.gov/show/NCT04393467 Recruiting Campus Bio-Medico University 2023-05-31
NCT04313166 Treatment Continuation Study for Patients With ALS/MND Who Completed Study CMD-2019-001 https://ClinicalTrials.gov/show/NCT04313166 Recruiting Collaborative Medicinal Development Pty Limited 2021-10-30
NCT04302870 Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial https://ClinicalTrials.gov/show/NCT04302870 Recruiting University of Edinburgh 2026-09-30
NCT04293484 Cortico-Spinal tDCS as Rehabilitative Intervention in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT04293484 Recruiting Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia 2020-12-31
NCT04254913 Clinical Pharmacology Study of Oral Edaravone in Amyotrophic Lateral Sclerosis Patients With Gastrostomy https://ClinicalTrials.gov/show/NCT04254913 Recruiting Mitsubishi Tanabe Pharma Corporation 2020-07-31
NCT04248465 An Efficacy and Safety Study of Ravulizumab in ALS Participants https://ClinicalTrials.gov/show/NCT04248465 Recruiting Alexion Pharmaceuticals 2022-09-30
NCT04245709 Clenbuterol on Motor Function in Individuals With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT04245709 Recruiting Duke University 2021-02-10
NCT04240925 Tolerability, Safety and Efficacy of Sigh Breaths During NIMV in Motor Neuron Disease https://ClinicalTrials.gov/show/NCT04240925 Recruiting Ospedale San Raffaele 2020-12-31
NCT04226144 Breath Stacking Technique Associated With Expiratory Muscle Training in Amyotrophic Lateral Sclerosis Patients https://ClinicalTrials.gov/show/NCT04226144 Recruiting Escola Superior de Ciencias da Saude 2021-08-31
NCT04220021 Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD https://ClinicalTrials.gov/show/NCT04220021 Recruiting University of Florida 2021-05-31
NCT04176224 Clinical Pharmacology Study of Oral Edaravone in Patients With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT04176224 Completed Mitsubishi Tanabe Pharma Corporation 2019-09-04
NCT04172792 Safety and Tolerability Ultra-high-caloric Food Supplements in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT04172792 Recruiting University of Ulm 2020-11-25
NCT04165850 Open Label Study to Evaluate Ciprofloxacin/Celecoxib Combination in Patients With ALS https://ClinicalTrials.gov/show/NCT04165850 Active, not recruiting NeuroSense Therapeutics Ltd. 2020-02-29
NCT04140136 The Efficacy and Safety of Vitamin E Mixed Tocotrienols In Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT04140136 Recruiting University of Malaya 2020-04-01
NCT04098406 Therapeutic Nanocatalysis to Slow Disease Progression of Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT04098406 Recruiting Clene Nanomedicine 2021-04-30
NCT04090684 Ciprofloxacin/Celecoxib Combination in Patients With ALS https://ClinicalTrials.gov/show/NCT04090684 Recruiting NeuroSense Therapeutics Ltd. 2020-12-31
NCT04082832 CuATSM Compared With Placebo for Treatment of ALS/MND https://ClinicalTrials.gov/show/NCT04082832 Recruiting Collaborative Medicinal Development Pty Limited 2020-12-30
NCT04066244 Study of Safety and of the Mechanism of BLZ945 in ALS Patients https://ClinicalTrials.gov/show/NCT04066244 Recruiting Novartis 2021-02-11
NCT04057898 Evaluation of MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients With ALS https://ClinicalTrials.gov/show/NCT04057898 Recruiting MediciNova 2023-12-31
NCT04055623 T-regulatory Cells in ALS https://ClinicalTrials.gov/show/NCT04055623 Active, not recruiting The Methodist Hospital System 2024-09-01
NCT03986671 Transmembrane Electromyography (TM-EMG) for the Assessment of Neuromuscular Function in the Oropharynx https://ClinicalTrials.gov/show/NCT03986671 Recruiting Powell Mansfield Inc. 2020-10-31
NCT03981536 A Study to Evaluate AP-101 in Familial and Sporadic Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT03981536 Recruiting AL-S Pharma 2020-08-31
NCT03975608 Psychological Therapy for Patients With ALS https://ClinicalTrials.gov/show/NCT03975608 Active, not recruiting University of Leipzig 2020-07-31
NCT03948178 Effects of Oral Levosimendan on Respiratory Function in Patients With ALS: Open-Label Extension https://ClinicalTrials.gov/show/NCT03948178 Recruiting Orion Corporation, Orion Pharma 2022-07-31
NCT03945279 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB100 Administered Orally to Adults With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03945279 Recruiting Biogen 2020-12-31
NCT03944447 Outcomes Mandate National Integration With Cannabis as Medicine https://ClinicalTrials.gov/show/NCT03944447 Recruiting OMNI Medical Services, LLC 2025-12-31
NCT03900247 Restore Motor Function Through Robotic Arm Exoskeleton and Brain Computer Interface https://ClinicalTrials.gov/show/NCT03900247 Enrolling by invitation University of Aarhus 2021-12-31
NCT03887338 Systematic Laryngoscopic Evaluation of Upper Airways in Ventilated ALS Patients in Portugal and in Norway https://ClinicalTrials.gov/show/NCT03887338 Recruiting Haukeland University Hospital 2021-12-31
NCT03883581 Impact of Nuedexta on Bulbar Physiology and Function in ALS https://ClinicalTrials.gov/show/NCT03883581 Recruiting University of Florida 2020-12-01
NCT03876002 Evaluation of Microglial Activation in ALS With [18F]PBR06 (Peripheral Benzodiazepine Receptor-06) PET https://ClinicalTrials.gov/show/NCT03876002 Completed Molecular NeuroImaging 2018-02-07
NCT03836716 Arimoclomol in Amyotropic Lateral Sclerosis - Open Label Extension Trial https://ClinicalTrials.gov/show/NCT03836716 Enrolling by invitation Orphazyme 2022-08-01
NCT03835507 Randomized, Double-blind, Safety and Efficacy of Recombinant Human Erythropoietin in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03835507 Recruiting Hanyang University Seoul Hospital 2020-12-31
NCT03828123 Autologous Multipotent Mesenchymal Stromal Cells in the Treatment of Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03828123 Completed Bioinova, s.r.o. 2017-08-18
NCT03811301 [BrainConnexion] - Neurodevice Phase II Trial https://ClinicalTrials.gov/show/NCT03811301 Recruiting National Neuroscience Institute 2021-12-31
NCT03809845 Serial Fasciculation Measurements in Motor Neurone Disease https://ClinicalTrials.gov/show/NCT03809845 Completed King’s College Hospital NHS Trust 2019-03-01
NCT03800524 Safety and Efficacy of TUDCA as add-on Treatment in Patients Affected by ALS https://ClinicalTrials.gov/show/NCT03800524 Recruiting Humanitas Mirasole SpA 2021-06-30
NCT03797677 MN4000 for Treatment of CF and MND Patients in the Home Setting https://ClinicalTrials.gov/show/NCT03797677 Completed Hill-Rom 2017-11-30
NCT03793868 Perampanel Single Ascending Dose Transcranial Magnetic Stimulation Biomarker Study in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03793868 Recruiting Mayo Clinic 2020-08-01
NCT03792490 Inhibition of Rho Kinase (ROCK) With Fasudil as Disease-modifying Treatment for ALS https://ClinicalTrials.gov/show/NCT03792490 Recruiting University Medical Center Goettingen 2021-10-31
NCT03787420 Development and Needs Assessment and Efficiency of Smart Communication System for Patients With ALS. https://ClinicalTrials.gov/show/NCT03787420 Recruiting Taipei Veterans General Hospital, Taiwan 2019-08-31
NCT03757351 Study to Evaluate DNL747 in Subjects With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03757351 Active, not recruiting Sanofi 2020-03-12
NCT03755167 A Follow up Study to Protocol 101/2 - Continued Treatment by IPL344 IV https://ClinicalTrials.gov/show/NCT03755167 Recruiting Immunity Pharma Ltd. 2022-11-30
NCT03707795 Treatment of FUS-Related ALS With Betamethasone - The TRANSLATE Study https://ClinicalTrials.gov/show/NCT03707795 Completed University of Kentucky 2019-01-10
NCT03705390 A Safety and Tolerability Study of ILB in Patients With Amyothrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT03705390 Recruiting University of Birmingham 2021-04-29
NCT03694132 Brain Excitability and Connectivity in Sensory-motor Pathways in ALS https://ClinicalTrials.gov/show/NCT03694132 Recruiting Institut National de la Santé Et de la Recherche Médicale, France 2019-12-31
NCT03693781 Colchicine for Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03693781 Recruiting Azienda Ospedaliero-Universitaria di Modena 2021-10-01
NCT03690791 Efficacy of Cannabinoids in Amyotrophic Lateral Sclerosis or Motor Neurone Disease https://ClinicalTrials.gov/show/NCT03690791 Recruiting Gold Coast Hospital and Health Service 2021-12-31
NCT03652805 A Study of IPL344 in the Treatment of ALS Patients https://ClinicalTrials.gov/show/NCT03652805 Recruiting Immunity Pharma Ltd. 2020-07-15
NCT03645031 Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease https://ClinicalTrials.gov/show/NCT03645031 Recruiting University of Florida 2021-03-31
NCT03626012 A Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 in Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03626012 Active, not recruiting Biogen 2021-09-28
NCT03618966 Neuromuscular Magnetic Stimulation in ALS Patients https://ClinicalTrials.gov/show/NCT03618966 Completed University of Roma La Sapienza 2016-05-01
NCT03613038 A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria https://ClinicalTrials.gov/show/NCT03613038 Recruiting University of Missouri-Columbia 2020-01-31
NCT03604822 Music Therapy Protocol to Support Bulbar and Respiratory Functions in ALS https://ClinicalTrials.gov/show/NCT03604822 Active, not recruiting Anglia Ruskin University 2018-07-31
NCT03580616 Tolerability and Efficacy of L-Serine in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT03580616 Recruiting Dartmouth-Hitchcock Medical Center 2022-06-30
NCT03573466 Presymptomatic Neuromuscular Junction Defects and Compensatory Mechanisms in ALS https://ClinicalTrials.gov/show/NCT03573466 Active, not recruiting Assistance Publique - Hôpitaux de Paris 2021-04-10
NCT03567213 Investigation on the Cortical Communication (CortiCom) System https://ClinicalTrials.gov/show/NCT03567213 Recruiting Johns Hopkins University 2024-11-30
NCT03545451 Neurofeedback Rehabilitation Based on Motor Imaging in Patients in the Immobilization Phase https://ClinicalTrials.gov/show/NCT03545451 Recruiting Assistance Publique - Hôpitaux de Paris 2021-06-30
NCT03520517 Open-label Study to Evaluate Safety, Tolerability and PK of BHV-0223 in ALS https://ClinicalTrials.gov/show/NCT03520517 Completed Biohaven Pharmaceuticals, Inc. 2018-10-08
NCT03516994 Reducing Disparities in the Quality of Advance Care Planning for Older Adults https://ClinicalTrials.gov/show/NCT03516994 Enrolling by invitation Duke University 2022-09-01
NCT03506425 A Pilot Trial of Triheptanoin for People With Amyotrophic Lateral Sclerosis (PALS) https://ClinicalTrials.gov/show/NCT03506425 Completed Duke University 2019-03-28
NCT03505021 Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS https://ClinicalTrials.gov/show/NCT03505021 Active, not recruiting Orion Corporation, Orion Pharma 2020-08-30
NCT03491462 Arimoclomol in Amyotropic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03491462 Active, not recruiting Orphazyme 2020-12-31
NCT03489200 EH301 for the Treatment of ALS https://ClinicalTrials.gov/show/NCT03489200 Completed Elysium Health 2017-06-30
NCT03488524 Open Label Extension Study of AMX0035 in Patients With ALS https://ClinicalTrials.gov/show/NCT03488524 Enrolling by invitation Amylyx Pharmaceuticals Inc. 2021-01-01
NCT03487263 Dose-Escalation, Safety and Pharmacokinetic Study of IC14 in Motor Neurone Disease https://ClinicalTrials.gov/show/NCT03487263 Completed Implicit Bioscience 2018-04-18
NCT03482050 A Study to Evaluate Transplantation of Astrocytes Derived From Human Embryonic Stem Cells, in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT03482050 Recruiting Kadimastem 2020-11-30
NCT03481348 Pharyngeal Electrical Stimulation in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03481348 Recruiting University of Ulm 2020-02-28
NCT03472950 Safety and Efficacy of Ranolazine for the Treatment of Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03472950 Recruiting University of Kansas Medical Center 2019-10-01
NCT03456882 The Effect of RNS60 on ALS Biomarkers https://ClinicalTrials.gov/show/NCT03456882 Active, not recruiting Mario Negri Institute for Pharmacological Research 2020-04-30
NCT03452618 Predictive Factors for the Diagnosis of Early Noninvasive Ventilation Equipment https://ClinicalTrials.gov/show/NCT03452618 Recruiting University Hospital, Toulouse 2019-11-30
NCT03411863 Cervical Electrical Stimulation for ALS https://ClinicalTrials.gov/show/NCT03411863 Active, not recruiting VA Office of Research and Development 2021-01-31
NCT01259050 Safety Study of High Doses of Zinc in ALS Patients https://ClinicalTrials.gov/show/NCT01259050 Completed Phoenix Neurological Associates, LTD 2012-01-31
NCT01257581 Safety and Efficacy Study of Creatine and Tamoxifen in Volunteers With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01257581 Completed Massachusetts General Hospital 2012-12-31
NCT01254539 Clinical Trial on The Use of Autologous Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis (Extension CMN/ELA) https://ClinicalTrials.gov/show/NCT01254539 Completed Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia 2015-11-20
NCT01232738 Trial of Safety and Efficacy of Rasagiline in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01232738 Completed University of Kansas Medical Center 2013-05-31
NCT01160367 Trial of Ascertaining Individual Preferences for Loved One’s Role in End-of-Life https://ClinicalTrials.gov/show/NCT01160367 Completed Johns Hopkins University 2014-03-26
NCT01160263 Study of Dopamine and Serotonin Transporters in Patients With Amyotrophic Lateral Sclerosis and Controls https://ClinicalTrials.gov/show/NCT01160263 Completed Assistance Publique - Hôpitaux de Paris 2014-10-31
NCT01154283 Study of Standard Noninvasive Positive Pressure Ventilation (NIPPV) and Low Expiratory Pressure NIPPV in ALS Patients https://ClinicalTrials.gov/show/NCT01154283 Completed University of Michigan 2011-10-31
NCT01142856 Mesenchymal Stem Cells for Treatment of Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01142856 Completed Mayo Clinic 2011-04-30
NCT01123200 An In-home Study of Brain Computer Interfaces https://ClinicalTrials.gov/show/NCT01123200 Completed University of Michigan 2011-05-31
NCT01123148 A P300 Brain Computer Interface to Operate Power Wheelchair Tilt https://ClinicalTrials.gov/show/NCT01123148 Completed University of Michigan 2010-08-31
NCT01119001 A P300 Brain Computer Interface Keyboard to Control Assistive Technology For Use by People With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT01119001 Completed University of Michigan 2010-08-31
NCT01091142 Single-Ascending-Dose Safety/Tolerability of NP001 in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01091142 Completed Neuraltus Pharmaceuticals, Inc. 2010-09-30
NCT01089010 A Study of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01089010 Completed Cytokinetics 2010-11-30
NCT01083667 SOD1 Inhibition by Pyrimethamine in Familial Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01083667 Completed Weill Medical College of Cornell University 2014-12-31
NCT01051882 Autologous Cultured Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF), in ALS Patients. https://ClinicalTrials.gov/show/NCT01051882 Completed Brainstorm-Cell Therapeutics 2012-12-31
NCT01041222 Safety, Tolerability, and Activity Study of ISIS SOD1Rx to Treat Familial Amyotrophic Lateral Sclerosis (ALS) Caused by SOD1 Gene Mutations https://ClinicalTrials.gov/show/NCT01041222 Completed Ionis Pharmaceuticals, Inc. 2011-12-31
NCT01020331 Memantine Therapy in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT01020331 Completed Phoenix Neurological Associates, LTD 2009-07-31
NCT00983983 High Fat/High Calorie Trial in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00983983 Completed Massachusetts General Hospital 2013-04-30
NCT00965497 Escitalopram (Lexapro) for Depression MS or ALS https://ClinicalTrials.gov/show/NCT00965497 Completed University of South Carolina 2010-03-31
NCT00958048 Effects of Nocturnal Non-invasive Ventilation in Patients With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00958048 Completed National Taiwan University Hospital 2013-04-30
NCT00956488 Supported Treadmill Ambulation Training (STAT) for Patients Diagnosed With Amyotrophic Lateral Aclerosis https://ClinicalTrials.gov/show/NCT00956488 Completed Atrium Health 2010-09-30
NCT00931944 Open-Label, Safety and Tolerability Extension Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS) (CL211) https://ClinicalTrials.gov/show/NCT00931944 Completed Knopp Biosciences 2013-07-31
NCT00925847 Effect of Lithium Carbonate in Patients With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00925847 Completed Assistance Publique - Hôpitaux de Paris 2011-04-30
NCT00919555 Combination Therapy in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00919555 Completed Phoenix Neurological Associates, LTD 2009-11-30
NCT00912041 BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia https://ClinicalTrials.gov/show/NCT00912041 Recruiting Massachusetts General Hospital 2022-09-30
NCT00879593 Nocturnal PtcCO2 Monitoring in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00879593 Completed Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche 2014-06-30
NCT00877604 Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00877604 Completed Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta 2011-07-31
NCT00875446 First Time in Human Study of GSK1223249 in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00875446 Completed GlaxoSmithKline 2011-09-09
NCT00868166 Safety and Efficacy of TRO19622 as add-on Therapy to Riluzole Versus Placebo in Treatment of Patients Suffering From ALS https://ClinicalTrials.gov/show/NCT00868166 Completed Hoffmann-La Roche 2011-09-30
NCT00860951 P300 Brain Computer Interface Keyboard to Operate Assistive Technology https://ClinicalTrials.gov/show/NCT00860951 Completed University of Michigan 2012-05-31
NCT00855400 Clinical Trial on the Use of Autologous Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00855400 Completed Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia 2009-10-31
NCT00847847 Neuromuscular Transmission in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00847847 Completed Assistance Publique - Hôpitaux de Paris 2012-04-30
NCT03237741 Bioavailability of GDC-0134 and the Effect of Food and Proton Pump Inhibitor on Pharmacokinetics of GDC-0134 in Healthy Female Participants https://ClinicalTrials.gov/show/NCT03237741 Completed Genentech, Inc. 2017-12-14
NCT00833820 Repetitive Transcranial Magnetic Stimulation (rTMS) in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00833820 Completed Catholic University of the Sacred Heart 2008-12-31
NCT00812851 Randomized Placebo-Controlled Crossover Trial With THC (Delta 9-Tetrahydrocannabinol) for the Treatment of Cramps in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00812851 Completed Cantonal Hospital of St. Gallen 2008-04-30
NCT01786174 Gilenya in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT01786174 Completed Massachusetts General Hospital 2014-09-30
NCT01771640 Intrathecal Transplantation of Mesenchymal Stem Cell in Patients With ALS https://ClinicalTrials.gov/show/NCT01771640 Completed Royan Institute 2014-10-31
NCT01424176 Dexpramipexole Renal PK Study https://ClinicalTrials.gov/show/NCT01424176 Completed Knopp Biosciences 2012-01-31
NCT03154450 EncoreAnywhere Use in Motor Neurone Disease https://ClinicalTrials.gov/show/NCT03154450 Completed Sheffield Teaching Hospitals NHS Foundation Trust 2017-04-01
NCT03039673 MIROCALS: Modifying Immune Response and OutComes in ALS https://ClinicalTrials.gov/show/NCT03039673 Active, not recruiting Centre Hospitalier Universitaire de Nīmes 2021-09-30
NCT02709330 ALS Reversals - Lunasin Regimen https://ClinicalTrials.gov/show/NCT02709330 Completed Duke University 2017-09-13
NCT04326283 Trial of Safety, Tolerability and Efficacy of Trametinib (SNR1611) in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT04326283 Recruiting Genuv Inc. 2022-03-31
NCT00748501 Clinical Trial of SB-509 in Subjects With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00748501 Completed Sangamo Therapeutics 2010-06-30
NCT00706147 Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00706147 Completed University of Miami 2014-12-31
NCT00696332 Talampanel for Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00696332 Completed Teva Pharmaceutical Industries 2010-04-30
NCT00800501 A Safety and Tolerability Study of Intracerebroventricular Administration of sNN0029 to Patients With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00800501 Completed Newron Sweden AB 2011-06-30
NCT00647296 Safety and Tolerability Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00647296 Completed Knopp Biosciences 2009-09-30
NCT00635960 Growth Hormone in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00635960 Completed Federico II University 2009-07-31
NCT00613899 Feasibility of Telesurveillance and Home Cough Assistance for Amyotrophic Lateral Patients (ALS) https://ClinicalTrials.gov/show/NCT00613899 Completed Fondazione Salvatore Maugeri 2008-03-31
NCT00600873 R(+)PPX High Dose Treatment of ALS https://ClinicalTrials.gov/show/NCT00600873 Completed Bennett, James P., Jr., M.D., Ph.D. 2008-09-30
NCT00580593 Trial of Early Noninvasive Ventilation for Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00580593 Completed University of Michigan 2012-03-31
NCT00542412 CARE Canadian ALS Riluzole Evaluation https://ClinicalTrials.gov/show/NCT00542412 Completed Sanofi NA
NCT00445172 A Long-Term Study in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00445172 Completed Eisai Inc. 2017-03-31
NCT00444613 A Study in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00444613 Completed Eisai Inc. 2014-03-31
NCT00424463 Expanded Controlled Study of Safety and Efficacy of MCI-186 in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00424463 Completed Mitsubishi Tanabe Pharma Corporation 2009-05-31
NCT00415519 Efficacy and Safety Study of MCI-186 for Treatment of Amyotrophic Lateral Sclerosis (ALS) Who Met Severity Classification III https://ClinicalTrials.gov/show/NCT00415519 Completed Mitsubishi Tanabe Pharma Corporation 2008-07-31
NCT00409721 The Effect of Memantine on Functional Outcomes and Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00409721 Completed University of Alberta 2010-12-31
NCT00403104 Placebo Controlled Study of ONO2506PO in the Presence of Riluzole in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00403104 Completed Ono Pharmaceutical Co. Ltd 2008-12-31
NCT00397423 G-CSF Treatment for Amyotrophic Lateral Sclerosis: A RCT Study Assessing Clinical Response https://ClinicalTrials.gov/show/NCT00397423 Completed Peking University NA
NCT00386464 Noninvasive Ventilation in ALS Patients With Mild Respiratory Involvement https://ClinicalTrials.gov/show/NCT00386464 Completed Johns Hopkins University NA
NCT00372879 Clinical Trial of Vitamin E to Treat Muscular Cramps in Patients With ALS https://ClinicalTrials.gov/show/NCT00372879 Completed Lawson Health Research Institute 2010-08-31
NCT00355576 Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00355576 Completed Columbia University NA
NCT00353665 Memantine for Disability in Amyotrophic Lateral Sclerosis (MEDALS) https://ClinicalTrials.gov/show/NCT00353665 Completed University of Lisbon 2008-06-30
NCT00349622 Clinical Trial Ceftriaxone in Subjects With ALS https://ClinicalTrials.gov/show/NCT00349622 Completed Massachusetts General Hospital 2012-11-30
NCT00330681 Efficacy and Safety Study of MCI-186 for Treatment of Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00330681 Completed Mitsubishi Tanabe Pharma Corporation 2008-09-30
NCT00326625 Clinical Trial of Glatiramer Acetate in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00326625 Completed Teva Pharmaceutical Industries 2008-06-30
NCT00324454 Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease https://ClinicalTrials.gov/show/NCT00324454 Completed Duke University 2007-12-31
NCT00298597 Influence of G-CSF and EPO on Associative Learning and Motor Skills https://ClinicalTrials.gov/show/NCT00298597 Completed University Hospital Muenster 2009-03-31
NCT00244244 A Multicenter, Dose Ranging Safety and Pharmacokinetics Study of Arimoclomol in ALS https://ClinicalTrials.gov/show/NCT00244244 Completed CytRx 2007-01-31
NCT00243932 Clinical Trial of High Dose CoQ10 in ALS https://ClinicalTrials.gov/show/NCT00243932 Completed Columbia University 2008-03-31
NCT00230074 A Long-term Extension Study of TCH346 and Placebo Administered Once Daily in Patients With Amyotrophic Lateral Sclerosis(ALS) https://ClinicalTrials.gov/show/NCT00230074 Completed Novartis 2005-02-28
NCT00214110 Tamoxifen Therapy in Amyotrophic Lateral Sclerosis [ALS] https://ClinicalTrials.gov/show/NCT00214110 Completed University of Wisconsin, Madison NA
NCT00204464 Study of the Effects Strengthening Exercises in Individuals With ALS https://ClinicalTrials.gov/show/NCT00204464 Completed University of Saskatchewan NA
NCT02414230 F 18 T807 Tau PET Imaging in Familial Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02414230 Active, not recruiting Washington University School of Medicine 2021-06-30
NCT00140452 Phase II Study Using Thalidomide for the Treatment of ALS https://ClinicalTrials.gov/show/NCT00140452 Completed Dartmouth-Hitchcock Medical Center NA
NCT00140218 R(+) Pramipexole in Early Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00140218 Completed Bennett, James P., Jr., M.D., Ph.D. 2007-01-31
NCT00136110 Trial of Sodium Valproate in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00136110 Completed UMC Utrecht NA
NCT00125203 Study of Myobloc in the Treatment of Sialorrhea (Drooling) in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00125203 Completed The University of Texas Health Science Center at San Antonio NA
NCT00116558 Early Treatment of Amyotrophic Lateral Sclerosis (ALS) With Nutrition and Non-Invasive Positive Pressure Ventilation https://ClinicalTrials.gov/show/NCT00116558 Completed University of Kentucky 2012-01-31
NCT00107770 Safety Study of Oral Sodium Phenylbutyrate in Subjects With ALS (Amyotrophic Lateral Sclerosis) https://ClinicalTrials.gov/show/NCT00107770 Completed VA Office of Research and Development 2006-11-30
NCT00076687 Safety Study of Botulinum Toxin Type A in Post-Upper Limb Stroke Patients With Reduced Lung Function https://ClinicalTrials.gov/show/NCT00076687 Completed Allergan 2009-08-31
NCT00072709 Study Evaluating TCH346 and Placebo Administered Once Daily in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00072709 Completed Novartis 2004-12-31
NCT00070993 Creatine for the Treatment of Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00070993 Completed National Center for Complementary and Integrative Health (NCCIH) NA
NCT00047723 Minocycline to Treat Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00047723 Completed National Institute of Neurological Disorders and Stroke (NINDS) NA
NCT00036413 A 12-week, Multicenter, Safety and Dose-ranging Study of 3 Oral Doses of TCH346 in Patients With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00036413 Completed Novartis 2002-10-31
NCT00035815 Insulin-like Growth Factor-1 in Amyotrophic Lateral Sclerosis (ALS) Trial https://ClinicalTrials.gov/show/NCT00035815 Completed Mayo Clinic 2007-08-31
NCT00694941 A Phase II Multi-centre, Extension Study to Investigate the Long Term Safety of ONO-2506PO in Patients Diagnosed With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00694941 Completed Ono Pharmaceutical Co. Ltd 2008-12-31
NCT00021697 Safety/Efficacy of AVP-923 in the Treatment of Emotional Lability (Uncontrolled Crying & Laughing) in Patients With ALS https://ClinicalTrials.gov/show/NCT00021697 Completed Avanir Pharmaceuticals 2002-04-30
NCT00005766 Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00005766 Completed National Center for Research Resources (NCRR) NA
NCT00005674 Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis [ALS] https://ClinicalTrials.gov/show/NCT00005674 Completed National Center for Research Resources (NCRR) NA
NCT00004771 Phase II Study of Leuprolide and Testosterone for Men With Kennedy’s Disease or Other Motor Neuron Disease https://ClinicalTrials.gov/show/NCT00004771 Completed Office of Rare Diseases (ORD) NA

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT04394871 Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing https://ClinicalTrials.gov/show/NCT04394871 Recruiting National Institutes of Health Clinical Center (CC) 2025-09-30
NCT03382392 Hypermetabolism in ALS Using Six REE Formulas https://ClinicalTrials.gov/show/NCT03382392 Completed University Hospital, Limoges 2014-11-30
NCT03378375 Resting Energy Expenditure Equations in Amyotrophic Lateral Sclerosis, Creation of a ALS-specific Equation https://ClinicalTrials.gov/show/NCT03378375 Completed University Hospital, Limoges 2014-11-30
NCT03362658 Novel MRI Biomarkers for Monitoring Disease Progression in ALS https://ClinicalTrials.gov/show/NCT03362658 Recruiting University of Alberta 2020-12-31
NCT04455542 Peripheral Neurofilament Levels and Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT04455542 Completed Peking University Third Hospital 2019-05-01
NCT03225144 Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia https://ClinicalTrials.gov/show/NCT03225144 Recruiting National Institutes of Health Clinical Center (CC) 2025-10-30
NCT03217396 Biomarkers of Synaptic Damage in Multiple Sclerosis https://ClinicalTrials.gov/show/NCT03217396 Recruiting Neuromed IRCCS 2020-09-01
NCT03095729 Cognitive Consequences of an Activation of the Cortical Drive to Breath (VENTIPSY) https://ClinicalTrials.gov/show/NCT03095729 Recruiting Association pour le Développement et l’Organisation de la Recherche en Pneumologie et sur le Sommeil 2020-10-31
NCT03090932 Longitudinal Study of Innate Lymphoid Cells in Peripheral Blood in ALS https://ClinicalTrials.gov/show/NCT03090932 Recruiting University of Michigan 2020-12-31
NCT03073239 Amyotrophic Lateral Sclerosis: a New Paradigm https://ClinicalTrials.gov/show/NCT03073239 Completed Conde, Bebiana, M.D. 2018-03-31
NCT03016897 ALS Testing Through Home-based Outcome Measures https://ClinicalTrials.gov/show/NCT03016897 Active, not recruiting Barrow Neurological Institute 2019-06-28
NCT04454892 Natural History and Clinical Features of Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT04454892 Recruiting Peking University Third Hospital 2030-12-01
NCT02964637 Diagnosing Frontotemporal Lobar Degeneration https://ClinicalTrials.gov/show/NCT02964637 Recruiting University Health Network, Toronto 2019-12-31
NCT02962050 Delineating Swallowing Impairment and Decline in ALS https://ClinicalTrials.gov/show/NCT02962050 Recruiting University of Florida 2022-06-30
NCT02893605 Study of Gene Polymorphisms Involved in the Metabolism and Action of Vitamin D in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02893605 Completed Centre Hospitalier Universitaire de Nīmes 2017-05-31
NCT02869048 Amyotrophic Lateral Sclerosis and the Innate Immune System https://ClinicalTrials.gov/show/NCT02869048 Recruiting Rigshospitalet, Denmark 2026-06-30
NCT02852278 A Patient Centric Motor Neuron Disease Activities of Daily Living Scale https://ClinicalTrials.gov/show/NCT02852278 Completed University of South Florida 2019-09-13
NCT02819765 Deep Phenotyping in Patients With ALS https://ClinicalTrials.gov/show/NCT02819765 Recruiting Barrow Neurological Institute 2020-07-31
NCT02795897 Genomic Translation for Amyotrophic Lateral Sclerosis Care https://ClinicalTrials.gov/show/NCT02795897 Recruiting Columbia University 2019-09-30
NCT02686268 Understanding Clinical Phenotype and Collecting Biomarker Samples in C9ORF72 ALS https://ClinicalTrials.gov/show/NCT02686268 Completed Washington University School of Medicine 2017-12-31
NCT02675075 DESIPHER_Speech Degradation as an Indicator of Physiological Degeneration in ALS https://ClinicalTrials.gov/show/NCT02675075 Completed VA Office of Research and Development 2017-12-31
NCT02611674 Methodology Study of Novel Outcome Measures to Assess Progression of ALS https://ClinicalTrials.gov/show/NCT02611674 Completed Biogen 2018-07-27
NCT02582385 In-situ Cytokines Expression in the CNS in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT02582385 Completed Brugmann University Hospital 2015-02-28
NCT02572479 Evaluating the Potential of the Diet as Disease Modifier in Amyotrophic Lateral Sclerosis (JERN_ALS) https://ClinicalTrials.gov/show/NCT02572479 Completed University of Jena 2018-10-31
NCT02124057 Study of Hepatic Function in Patients With Spinal and Bulbar Muscular Atrophy https://ClinicalTrials.gov/show/NCT02124057 Recruiting National Institutes of Health Clinical Center (CC) 2020-12-31
NCT02559869 Imaging and BioFluid Biomarkers in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02559869 Completed Massachusetts General Hospital 2019-06-28
NCT02532244 Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases https://ClinicalTrials.gov/show/NCT02532244 Recruiting Nemours Children’s Clinic 2022-12-31
NCT02528071 Prognostic Value of a Diaphragmatic Endurance Test in Patients With Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02528071 Recruiting Centre Hospitalier Universitaire de Saint Etienne 2021-04-30
NCT02507713 Quantitative Neuromuscular Ultrasonography in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT02507713 Completed Universidad Católica San Antonio de Murcia 2014-04-30
NCT02457715 Feasibility of a Consumer Based Accelerometer in Monitoring Outpatient Physical Activity: A Study in Patients With Cancer and Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02457715 Completed Duke University 2017-10-31
NCT02405182 MRI Biomarkers in ALS https://ClinicalTrials.gov/show/NCT02405182 Completed University of Alberta 2019-03-31
NCT02365922 Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) https://ClinicalTrials.gov/show/NCT02365922 Recruiting University of California, San Francisco 2020-09-30
NCT02327845 Phenotype, Genotype & Biomarkers in ALS and Related Disorders https://ClinicalTrials.gov/show/NCT02327845 Recruiting University of Miami 2021-06-30
NCT02325375 sCD163 in ALS Patients https://ClinicalTrials.gov/show/NCT02325375 Completed University of Aarhus 2016-02-29
NCT02228915 Analysis of Post-Translational Modifications of a Critical Protein Implicated in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT02228915 Completed University of North Carolina, Chapel Hill 2018-10-14
NCT03356288 The General Breathing Record Study https://ClinicalTrials.gov/show/NCT03356288 Completed Cambridge Respiratory Innovations Limited 2018-07-04
NCT02011204 Study of Electrical Impedance Myography (EIM) in ALS https://ClinicalTrials.gov/show/NCT02011204 Completed Skulpt, Inc. 2016-03-31
NCT01948102 Identification of Diagnostic And Prognostic Biomarkers From Amyotrophic Lateral Sclerosis (ALS) Skin and Adipose Samples https://ClinicalTrials.gov/show/NCT01948102 Completed Atrium Health 2014-08-06
NCT01925196 Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation https://ClinicalTrials.gov/show/NCT01925196 Active, not recruiting National Institutes of Health Clinical Center (CC) 2020-12-31
NCT01911130 Longitudinal Study of Outcomes Measures in ALS Trials https://ClinicalTrials.gov/show/NCT01911130 Completed Massachusetts General Hospital 2015-06-30
NCT01889043 Monitoring of Non-invasive Ventilation During Sleep in ALS https://ClinicalTrials.gov/show/NCT01889043 Completed Universitaire Ziekenhuizen Leuven 2015-09-30
NCT01803386 Noninvasive Assessment of Neuromuscular Disease Using Electrical Impedance Myography https://ClinicalTrials.gov/show/NCT01803386 Completed Skulpt, Inc. 2015-03-31
NCT01772888 Chewing Efficiency Measured by a Two Colour Chewing Gum Test in Amyotrophic Lateral Sclerosis (ALS) Patients? https://ClinicalTrials.gov/show/NCT01772888 Completed University Hospital, Geneva 2019-07-31
NCT01699451 DNA, Blood and Skin Cell Repository for Research on ALS and Related Neurodegenerative Disorders at Mayo Clinic Florida https://ClinicalTrials.gov/show/NCT01699451 Enrolling by invitation Mayo Clinic 2032-12-31
NCT01592552 A Biospecimen and Clinical Data Study on Patients With Alzheimer’s, Multiple Sclerosis, Parkinson’s, and Huntington’s, for Drug & Biomarker Discovery https://ClinicalTrials.gov/show/NCT01592552 Completed Sanguine Biosciences 2015-03-31
NCT01592084 Hyperlipidemia and Statin Therapy in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT01592084 Completed The Methodist Hospital System 2011-09-30
NCT01508962 PRE-Symptomatic Studies in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT01508962 Active, not recruiting University of Miami 2027-12-31
NCT01495390 A Longitudinal Study of Amyotrophic Lateral Sclerosis (ALS) Biomarkers https://ClinicalTrials.gov/show/NCT01495390 Completed Massachusetts General Hospital 2016-12-31
NCT01459302 Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders https://ClinicalTrials.gov/show/NCT01459302 Recruiting University of Massachusetts, Worcester 2021-10-31
NCT01366027 PRISM Registry: Pseudobulbar Affect Registry Series https://ClinicalTrials.gov/show/NCT01366027 Completed Avanir Pharmaceuticals 2012-09-30
NCT04440644 Italian Validation of the Beaumont Behavioural Inventory (BBI) https://ClinicalTrials.gov/show/NCT04440644 Recruiting Istituti Clinici Scientifici Maugeri SpA 2020-09-30
NCT04363684 ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) https://ClinicalTrials.gov/show/NCT04363684 Recruiting Mayo Clinic 2024-07-31
NCT04259255 Radicava® (Edaravone) Findings in Biomarkers From ALS (REFINE-ALS) https://ClinicalTrials.gov/show/NCT04259255 Recruiting Mitsubishi Tanabe Pharma America Inc. 2022-02-28
NCT04233099 Salivary Biomarker Discovery by Raman Spectroscopy in ALS (SalivALS) https://ClinicalTrials.gov/show/NCT04233099 Recruiting Fondazione Don Carlo Gnocchi Onlus 2020-03-30
NCT04150809 A Study to Explore the Role of Gut Flora in ALS https://ClinicalTrials.gov/show/NCT04150809 Recruiting ProgenaBiome 2023-03-31
NCT04104373 The Ontario Neurodegenerative Disease Research Initiative https://ClinicalTrials.gov/show/NCT04104373 Completed Ontario Neurodegeneration Disease Research Initiative 2018-03-31
NCT04097158 Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone https://ClinicalTrials.gov/show/NCT04097158 Recruiting Loma Linda University 2021-09-30
NCT04051333 The E-health Application To Modify ORal Energy Intake and Measure Outcomes REmotely in ALS Clinical Trial (EAT MORE2) https://ClinicalTrials.gov/show/NCT04051333 Recruiting Massachusetts General Hospital 2021-09-30
NCT04026581 Real World Testing of a Brain-Computer Interface https://ClinicalTrials.gov/show/NCT04026581 Recruiting University of Pittsburgh 2022-08-31
NCT04008329 A Registered Cohort Study on Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT04008329 Recruiting First Affiliated Hospital of Fujian Medical University 2029-07-31
NCT03868345 Speech Analysis in ALS Patients https://ClinicalTrials.gov/show/NCT03868345 Recruiting Barrow Neurological Institute 2019-08-31
NCT03865420 Amyotrophic Lateral Sclerosis (ALS) Families Project https://ClinicalTrials.gov/show/NCT03865420 Recruiting Columbia University 2021-09-30
NCT03806647 Development and Needs Assessment and Efficiency of Smart Communication System for Patients With ALS (Part 1) https://ClinicalTrials.gov/show/NCT03806647 Recruiting Taipei Veterans General Hospital, Taiwan 2020-04-01
NCT03764384 Validation Of Tidal/End -Tidal CO2 in ALS https://ClinicalTrials.gov/show/NCT03764384 Active, not recruiting Papworth Hospital NHS Foundation Trust 2020-06-04
NCT03664206 Assessing Motor Neuron Disease Mechanisms by Threshold Tracking Transcranial Magnetic Stimulation and Magnetic Resonance Spectroscopy https://ClinicalTrials.gov/show/NCT03664206 Enrolling by invitation Aarhus University Hospital 2019-08-31
NCT03579017 Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen in Norway: A Validation Study https://ClinicalTrials.gov/show/NCT03579017 Recruiting Haukeland University Hospital 2021-12-31
NCT03578796 Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen in Norway: A Prospective Cohort Study https://ClinicalTrials.gov/show/NCT03578796 Recruiting Haukeland University Hospital 2021-12-31
NCT03560661 Acoustic and Perceptual Markers of Dysarthria in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT03560661 Completed Assistance Publique - Hôpitaux de Paris 2019-12-23
NCT03489278 Clinical Procedures to Support Research in ALS https://ClinicalTrials.gov/show/NCT03489278 Recruiting University of Miami 2024-06-30
NCT03449212 SOD1 Kinetics Measurements in ALS Patients https://ClinicalTrials.gov/show/NCT03449212 Recruiting Washington University School of Medicine 2020-05-31
NCT01143428 Oxidative Stress in Motor Neuron Disease: COSMOS Add-On Study https://ClinicalTrials.gov/show/NCT01143428 Completed National Institutes of Health Clinical Center (CC) NA
NCT01090674 Relationship Between Respiratory Functional Tests and Image Thoracic Techniques in Patients With Neuromuscular Diseases https://ClinicalTrials.gov/show/NCT01090674 Completed Fundació Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau 2013-07-31
NCT00956501 Assessment of Postural Orientation and Equilibrium In Early Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00956501 Completed Atrium Health 2010-02-28
NCT00838617 Muscle Ultrasound: A New Tool for Measuring Progression in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00838617 Completed Vanderbilt University 2009-08-31
NCT00821132 Genetics of Familial and Sporadic ALS https://ClinicalTrials.gov/show/NCT00821132 Recruiting Northwestern University 2019-12-31
NCT03912987 TRIAL READY (Clinical Trial Readiness) https://ClinicalTrials.gov/show/NCT03912987 Recruiting University of Miami 2022-01-31
NCT00809224 Cortex Changes in Real/Imagined Movements in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00809224 Completed University of Michigan 2012-05-31
NCT00801333 Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells https://ClinicalTrials.gov/show/NCT00801333 Recruiting Hadassah Medical Organization 2025-12-31
NCT03088839 Circulating Biomarker for Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT03088839 Recruiting Neuromed IRCCS 2019-09-01
NCT02567136 Imaging Biomarkers in ALS https://ClinicalTrials.gov/show/NCT02567136 Active, not recruiting University of Minnesota 2025-09-30
NCT04446325 Venous Disease Thromboembolic and Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT04446325 Recruiting University Hospital, Brest 2020-09-01
NCT00786032 A Clinical Demonstration of EEG Brain-computer Interface for ALS Patients https://ClinicalTrials.gov/show/NCT00786032 Completed VA Office of Research and Development 2013-06-30
NCT00718497 Comparing The Cyberlink Control System to the Manual Letter Board for Communication Purposes in the ALS Patient Population https://ClinicalTrials.gov/show/NCT00718497 Completed Drexel University 2012-05-31
NCT00718458 EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00718458 Completed Drexel University 2016-12-31
NCT00718393 Compassionate Use of Ceftriaxone in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00718393 Completed Drexel University 2015-10-31
NCT00716131 Amyotrophic Lateral Sclerosis (ALS) Tissue Donation Program https://ClinicalTrials.gov/show/NCT00716131 Completed Drexel University 2016-11-30
NCT00714805 Non-Invasive Measurement of Gastrointestinal (GI) Motility in Patients With Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00714805 Completed Drexel University 2016-11-30
NCT00714636 Cerebrospinal Fluid Repository https://ClinicalTrials.gov/show/NCT00714636 Completed Drexel University 2008-10-31
NCT00677768 Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00677768 Completed Massachusetts General Hospital 2015-11-30
NCT00620698 Electrical Impedance Myography as an Outcome Measure in Amyotrophic Lateral Sclerosis Clinical Trials https://ClinicalTrials.gov/show/NCT00620698 Completed Beth Israel Deaconess Medical Center 2011-03-31
NCT00537641 Efficacy of Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT00537641 Completed Columbia University 2010-07-31
NCT00377351 Confirmation of Self-Reported Incident ALS Cases in the AARP-Diet and Health (AARP-DH) Cohort https://ClinicalTrials.gov/show/NCT00377351 Completed National Institutes of Health Clinical Center (CC) NA
NCT00362362 Collection of Blood Samples for DNA in Motor Neuron Disease https://ClinicalTrials.gov/show/NCT00362362 Completed National Institutes of Health Clinical Center (CC) NA
NCT00339976 Exposure to Neurotoxins as Risk Factors for Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00339976 Completed National Institutes of Health Clinical Center (CC) NA
NCT00337402 Effects of Gastrostomy on Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00337402 Completed University Hospital, Clermont-Ferrand NA
NCT00334516 Brain Function in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00334516 Completed National Institutes of Health Clinical Center (CC) NA
NCT00317616 The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study https://ClinicalTrials.gov/show/NCT00317616 Recruiting University of Miami 2027-12-31
NCT00302198 Amyotrophic Lateral Sclerosis Web Based Patient Care Database: ALSConnection.Org https://ClinicalTrials.gov/show/NCT00302198 Completed Forbes Norris MDA/ALS Research Center 2010-02-28
NCT00136500 Clinical Research in ALS Study https://ClinicalTrials.gov/show/NCT00136500 Recruiting University of Miami 2027-12-31
NCT00076154 National Registry of Veterans With Amyotrophic Lateral Sclerosis and DNA Bank https://ClinicalTrials.gov/show/NCT00076154 Completed VA Office of Research and Development 2007-09-30
NCT00071435 Brain Function in Primary Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00071435 Completed National Institutes of Health Clinical Center (CC) NA
NCT00023075 Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00023075 Completed National Institutes of Health Clinical Center (CC) NA
NCT00606918 Validation of a New Device to Measure Neuromuscular Disease Progression https://ClinicalTrials.gov/show/NCT00606918 Completed Massachusetts General Hospital 2010-09-30
NCT00015444 Screening and Natural History: Primary Lateral Sclerosis and Related Disorders https://ClinicalTrials.gov/show/NCT00015444 Completed National Institutes of Health Clinical Center (CC) NA
NCT00011154 Exogenous Toxicants and Genetic Susceptibility in ALS https://ClinicalTrials.gov/show/NCT00011154 Completed National Institute of Environmental Health Sciences (NIEHS) NA
NCT00007722 Amyotrophic Lateral Sclerosis (ALS) Gulf War Study https://ClinicalTrials.gov/show/NCT00007722 Completed VA Office of Research and Development 2003-03-31
NCT00004568 Study of Inherited Neurological Disorders https://ClinicalTrials.gov/show/NCT00004568 Recruiting National Institutes of Health Clinical Center (CC) NA
NCT00001780 Magnetic Stimulation of the Human Nervous System https://ClinicalTrials.gov/show/NCT00001780 Completed National Institutes of Health Clinical Center (CC) NA
NCT00001220 Ultrasound and Videofluoroscopy for Diagnosing Swallowing Disorders https://ClinicalTrials.gov/show/NCT00001220 Completed National Institutes of Health Clinical Center (CC) NA
NCT00001185 Study of “Post-Polio Syndrome” https://ClinicalTrials.gov/show/NCT00001185 Completed National Institutes of Health Clinical Center (CC) NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT03366506 Investigation of the Epidemiological Factors Associated With the Development of Amyotrophic Lateral Sclerosis (ALS) https://ClinicalTrials.gov/show/NCT03366506 Recruiting Hadassah Medical Organization 2049-03-31
NCT02942953 Diaphragmatic Pacer Placement: Anesthetic Management (DP) https://ClinicalTrials.gov/show/NCT02942953 Completed Institut Guttmann 2015-10-31
NCT02916966 Population-Based Ohio Amyotrophic Lateral Sclerosis (ALS) Repository and ALS Risk Factors https://ClinicalTrials.gov/show/NCT02916966 Completed Dartmouth-Hitchcock Medical Center 2019-09-30
NCT02574390 Answer ALS: Individualized Initiative for ALS Discovery https://ClinicalTrials.gov/show/NCT02574390 Completed Johns Hopkins University 2019-12-31
NCT02360891 Study of Predictive Factors of Progression of Motor Neurone Disease https://ClinicalTrials.gov/show/NCT02360891 Recruiting University Hospital, Lille 2025-01-31
NCT03683875 Ultrasonography of the Neuromuscular Degeneration Behavior in Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT03683875 Recruiting Hospital General Universitario Santa Lucia 2019-10-31
NCT01955369 Amyotrophic Lateral Sclerosis Registry Rhineland-Palatinate https://ClinicalTrials.gov/show/NCT01955369 Completed Klinikum Ludwigshafen 2012-09-30
NCT01772602 The National Amyotrophic Lateral Sclerosis Registry https://ClinicalTrials.gov/show/NCT01772602 Recruiting Centers for Disease Control and Prevention 2025-12-31
NCT04328675 Registration Study of Amyotrophic Lateral Sclerosis (ALS) in Mainland China https://ClinicalTrials.gov/show/NCT04328675 Recruiting Peking University Third Hospital 2023-03-20
NCT03706391 Study of ALS Reversals 4: LifeTime Exposures https://ClinicalTrials.gov/show/NCT03706391 Enrolling by invitation Duke University 2020-08-01
NCT03464903 Study of ALS Reversals 2: Genetic Analyses https://ClinicalTrials.gov/show/NCT03464903 Enrolling by invitation Duke University 2020-08-01